Загруженный файл CV

Education

• Sept 2023 – Present
  PhD Candidate
  German Cancer Research Center (DKFZ), Partner Site – German Cancer Consortium (DKTK), University Carl Gustav Carus, Dresden, Germany

• Sept 2020 – August 2022
  Erasmus University Rotterdam, Rotterdam, Netherlands
  Qualification: Master of Science in Molecular Medicine

• Sept 2017 – June 2020
  IMC University of Applied Sciences, Krems, Austria
  Medical and Pharmaceutical Biotechnology
  Qualification: Bachelor of Science in Engineering

• Sept 2014 – June 2017
  Centre of excellence in medicine and pharmacy “R. Pacalo”, Chisinau, Moldova
  General nursing studies
  Qualification: Bacalaureat Diploma

Work Experience/ Internships

• October 2022 – July 2023
  Research Associate II, Department of Oncology
  Hubrecht Organoid Technology (HUB), Yalelaan 61, 3584CM Utrecht, the Netherlands
  Responsibilities: Derive organoids from colorectal cancer biopsies, drug screening assays, CRISPR-Cas9 screens, electroporation, molecular biology techniques (RNA/DNA/protein isolation, RT-qPCR, Western Blotting, immunofluorescence assays), project management, technology transfer support.

• September 2021 – July 2022
  Second Master research project “BIRC5 - a novel potential therapeutic target for ARID1A-deficient bladder cancer”
  Erasmus Medical Center, Department of Molecular Genetics, Tokameh Mahmoudi group, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands
  Responsibilities: Identify potential therapeutic targets for ARID1A-deficient bladder tumors - derive organoids from bladder cancer biopsies, lentiviral-mediated shRNA transduction, drug screening assays, FACS, analysis of gene and protein expression (RNA isolation, RT-qPCR, immunohistochemistry, RNA sequencing, immunofluorescence assay), drug screenings, confocal imaging, data analysis, design experiments, MS Office skills, project leader support, student supervision, scientific writing

• October 2020 – June 2021
  First Master research project “Generating a MYBPC3-deficient iPS-derived cardiomyocyte isogenic cell line for modelling hypertrophic cardiomyopathy”
  Erasmus Medical Center, Department of Molecular Genetics, Jeroen Essers group, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands
  Responsibilities: Analyze the role of MYCB3 in hypertrophic cardiomyopathy - derive cardiomyocytes from human induced PSCs, CRISPR-Cas9 genome editing, molecular biology techniques (RNA/DNA isolation, PCR, RT-qPCR) immunofluorescence assays, data analysis, MS Office skills

• September 2019 – February 2020
  Bachelor’s research project “The effects of protein-bound uremic toxins on inflammasome activation in renal proximal tubule cells”
  Utrecht University, Department of Pharmaceutical Sciences, Prof. Roos Masereeuw group, Universiteitsweg 99, Utrecht, the Netherlands
  Responsibilities: Identify the effects of protein-bound uremic toxins on inflammasome activation - mammalian cell culture, analysis of gene and protein expression (RNA/DNA/protein isolation, protein quantification, ELISA, Western Blotting, RT-qPCR, immunofluorescence), confocal microscopy, data analysis, MS Office skills, scientific writing

Language Skills

• English: C1
• German: A2
• Romanian: mother tongue
• Russian: mother tongue
• Korean: A1

Publications

• Scholtes MP, Akbarzadeh M, Galaras A, Nakauma-Gonzáles JA, Bazrafshan A, Solanki V, Torenvliet B, Beikmohammadi L, Lozovanu V, Romal S, Moulos P, Vavouraki N, Kan TW, Algoe M, van Royen ME, Sacchetti A, van den Bosch TPP, Eussen B, de Klein A, van Leenders GJLH, Boormans JL, Hatzis P, Palstra RJ, Zuiverloon TCM, Mahmoudi T. Integrative analysis of patient-derived tumoroids and ex vivo organoid modelling of ARID1A loss in bladder cancer reveals therapeutic molecular targets. Cancer Lett. 2025 Apr 1;614:217506. doi: 10.1016/j.canlet.2025.217506. Epub 2025 Jan 30. PMID: 39892702.

• Mihajlovic M, Krebber MM, Yang Y, Ahmed S, Lozovanu V, Andreeva D, Verhaar MC, Masereeuw R. “Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells.” Biomedicines. 2021 Sep 26;9(10):1326. doi: 10.3390/biomedicines9101326. PMID: 34680443; PMCID: PMC8533138.